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Pentacyclic triterpenoid compounds as topoisomerase inhibitors or cell differentiation inducers

Lee, Y., Fang, Q., Wang, Z., Li, D., & Cook, C. (1991). Pentacyclic triterpenoid compounds as topoisomerase inhibitors or cell differentiation inducers. (U.S. Patent No. 5064823). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=5064823

Abstract

Pentacyclic triterpenoid compounds such as .alpha. boswelic acid and its acetate, .beta.-boswellic acid and its acetate, which have an inhibitory effect on topoisomerase I and topoisomerase II, are disclosed. Compositions based on the pentacyclic triterpenoid compounds which can be used to treat various cancers in mammals are also disclosed.

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