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This chapter of the 2020 Report of the FABLE Consortium Pathways to Sustainable Land-Use and Food Systems outlines how sustainable food and land-use systems can contribute to raising climate ambition, aligning climate mitigation and biodiversity protection policies, and achieving other sustainable development priorities in the United States (e.g., healthier diets). It presents three pathways for food and land-use systems for the period 2020-2050: Current Trends, Sustainable Medium Ambition, and Sustainable High Ambition (referred to as “Current Trends”, “Sustainable”, and “Sustainable +” in all figures throughout this chapter). These pathways examine the trade-offs between achieving the FABLE Targets under limited land availability and constraints to balance supply and demand at national and global levels. We developed these pathways using government sources and academic literature, and modeled them with the FABLE Calculator (Mosnier, Penescu, Thomson, and Perez-Guzman, 2019). See Annex 1 for more details on the adaptation of the model to the national context.