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Nanoparticles featuring amino acid-functionalized side chains as DNA receptors
Ghosh, P. S., Han, G., Erdogan, B., Rosado, O., Krovi, S. A., & Rotello, V. M. (2007). Nanoparticles featuring amino acid-functionalized side chains as DNA receptors. Chemical Biology and Drug Design, 70(1), 13-8. https://doi.org/10.1111/j.1747-0285.2007.00534.x
A family of nanoparticles has been fabricated featuring cationic amino acid-based side chains. This controlled surface modification provides a tool to investigate the effect of various non-covalent interactions at the nanoparticle-DNA interface. The binding affinities of these nanoparticles towards DNA were determined using fluorescence, exhibiting more than threefold modulation in binding a 37-mer DNA strand. The secondary structure of the DNA strand was distorted upon nanoparticle binding, with the extent of distortion dependent on the structure of amino acid side chain.
