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The present invention provides methods of treating malignant
colon and colo-rectal cancer in mammals, by reducing or inhibiting
or retarding such colon cancer tumors in mammals. These methods
employ the administration of a tumor-inhibiting or reducing
camptothecin compound, e.g., 9-amino-20(RS)-camptothecin,
10,11-methylenedioxy-20(RS)-camptothecin, and the sodium salt of
10,11-methylenedioxy-20(RS)-camptothecin, or a combination thereof.
Also provided are pharmaceutical formulations.