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A camptothecin analog having the structure shown below: ##STR1##
where Z is H or C.sub.1-8 alkyl and R is NO.sub.2, NH.sub.2,
N.sub.3, hydrogen, halogen, COOH, OH, O-C.sub.1-3 alkyl, SH,
S-C.sub.1-3 alkyl, CN, CH.sub.2 NH.sub.2, NH-C.sub.1-3 alkyl,
CH.sub.2 -NH-C.sub.1-3 alkyl, N(C.sub.1-3 alkyl).sub.2, CH.sub.2
N(C.sub.1-3 alkyl).sub.2, O-, NH- or S-CH.sub.2 CH.sub.2 N(CH.sub.2
CH.sub.2 OH).sub.2, O-, NH- or S- CH.sub.2 CH.sub.2 CH.sub.2
N(CH.sub.2 CH.sub.2 OH).sub.2, O-, NH- or S-CH.sub.2 CH.sub.2
N(CH.sub.2 CH.sub.2 CH.sub.2 OH).sub.2, O-, NH- or S-CH.sub.2
CH.sub.2 CH.sub.2 N(CH.sub.2 CH.sub.2 OH.sub.2).sub.2, O-, NH- or
S-CH.sub.2 CH.sub.2 N(C.sub.1-3 alkyl).sub.2, O-, NH- or S-CH.sub.2
CH.sub.2 CH.sub.2 N(C.sub.1-3 alkyl).sub.2, CHO, C.sub.1-3 alkyl or
NHCOCHR.sup.1 NR.sup.2 R.sup.3, where R.sup.1 is the side-chain of
an .alpha.-amino acid and R.sup.2 and R.sup.3, independently are
hydrogen or a lower alkyl group or R.sup.3 is a peptide unit
containing 1-3 amino acid units bonded to the nitrogen through a
peptide bond; NHCO-C.sub.2-8 -alkylene-X or NHCO-C.sub.2-8
-alkenylene-X, where X is COOH; CONR.sup.2 -(CH.sub.2).sub.n
-NR.sup.2 R.sup.3, where n=1-10 and R.sup.2 and R.sup.3 are as
defined above; NHCO-B-(CH.sub.2).sub.n-NR.sup.2 R.sup.3, where
B=oxygen or NH, or ##STR2## where m+y=3-6, and salts thereof. The
campothecin compounds inhibit the enzyme topisomerase I and are
useful in treating tumors and leukemia.