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Method for making cocaine receptor binding ligands and intermediates therefor

Carroll, F. (2000). Method for making cocaine receptor binding ligands and intermediates therefor. (U.S. Patent No. 6123917). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=6123917

Abstract

An improved method for preparation of cocaine receptor binding ligands is provided. The method calls for the preparation of the silylaryl intermediate prepared from phenyl trimethylsilane and a anhydroecgonine methyl ester appropriately substituted. The intermediate is prepared in high purity and can be directly converted to the binding ligand by iodine substitution.

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