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Flexible, large area electronics - macroelectronics - using amorphous silicon, low-temperature polysilicon, or various organic and inorganic nanocrystalline semiconductor materials is beginning to show great promise. While much of the activity in macroelectronics has been display-centric, a number of applications where macroelectronics is needed to enable solutions that are otherwise not feasible are beginning to attract technical and/or commercial interest. In this paper, we discuss the application drivers and the technology needs and device performance requirements to enable high performance applications to include RF systems.