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Ligands for nAChRs are provided based on various derivatives of
methyllycaconitine (MLA) such as radiolabeled MLA, and MLA
containing a fluorimetric marker group and their use in imaging for
detection of Alzheimer's and other CNS diseases, and combinatorial
assays for detection of compounds having affinity for nAChRs, as
well as injectable compositions containing the same and kits for
performing the imaging studies.