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Increased risk of acute hepatitis B among adults with diagnosed diabetes mellitus
Reilly, ML., Schillie, SF., Smith, E., Poissant, T., Vonderwahl, CW., Gerard, C., Baumgartner, J., Mercedes, L., Sweet, K., Muleta, D., Zaccaro, D., Klevens, RM., & Murphy, TV. (2012). Increased risk of acute hepatitis B among adults with diagnosed diabetes mellitus. Journal of diabetes science and technology, 6(4), 858-866. http://www.journalofdst.org/July2012/PDF/Abstracts/VOL-6-4-ORG1-REILLY-ABSTRACT.pdf
Introduction: The risk of acute hepatitis B among adults with diabetes mellitus is unknown. We investigated the association between diagnosed diabetes and acute hepatitis B. Methods: Confirmed acute hepatitis B cases were reported in 2009–2010 to eight Emerging Infections Program (EIP) sites; diagnosed diabetes status was determined. Behavioral Risk Factor Surveillance System respondents residing in EIP sites comprised the comparison group. Odds ratios (ORs) comparing acute hepatitis B among adults with diagnosed diabetes versus without diagnosed diabetes were determined by multivariate logistic regression, adjusting for age, sex, and race/ethnicity, and stratified by the presence or absence of risk behaviors for hepatitis B virus (HBV) infection. Results: During 2009–2010, EIP sites reported 865 eligible acute hepatitis B cases among persons aged ?23 years; 95 (11.0%) had diagnosed diabetes. Comparison group diabetes prevalence was 9.1%. Among adults without hepatitis B risk behaviors and with reported diabetes status, the OR for acute hepatitis B comparing adults with and without diabetes was 1.9 (95% confidence interval [CI] = 1.4, 2.6); ORs for adults ages 23–59 and ?60 years were 2.1 (95% CI = 1.6, 2.8) and 1.5 (95% = CI 0.9, 2.5), respectively. Conclusions: Diabetes was independently associated with an increased risk for acute hepatitis B among adults without HBV risk behaviors.