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Improved anti-proliferative effect of doxorubicin-containing polymer nanoparticles upon surface modification with cationic groups
Krovi, S. A., Swindell, E. P., O'Halloran, T. V., & Nguyen, S. T. (2012). Improved anti-proliferative effect of doxorubicin-containing polymer nanoparticles upon surface modification with cationic groups. Journal of Materials Chemistry, 22(48), 25463-25470. https://doi.org/10.1039/C2JM35420A
Polymer nanoparticles (PNPs) possessing a high density of drug payload have been successfully stabilized against aggregation in biological buffers after amine modification, which renders these PNPs positively charged. The resulting charge-stabilized PNPs retain their original narrow particle size distributions and well-defined spherical morphologies. This stabilization allows these PNPs to have an improved anti-proliferative effect on MDA-MB-231-Br human breast cancer cells compared to non-functionalized PNPs. As a non-cytotoxic control, similar surface-modified PNPs containing cholesterol in place of doxorubicin did not inhibit cell proliferation, indicating that the induced cytotoxic response was solely due to the doxorubicin release from the PNPs.
