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Fabrication of polyethylene terephthalate (PET) nanoparticles with fluorescent tracers for studies in mammalian cells
Johnson, L. M., Mecham, J. B., Krovi, S. A., Moreno Caffaro, M. M., Aravamudhan, S., Kovach, A. L., Fennell, T. R., & Mortensen, N. P. (2021). Fabrication of polyethylene terephthalate (PET) nanoparticles with fluorescent tracers for studies in mammalian cells. Nanoscale Advances, 3(2), 339-346. https://doi.org/10.1039/d0na00888e
Fluorescent nanoparticles (NPs) comprising polyethylene terephthalate (PET) with a hydrodynamic diameter of 158 ± 2 nm were synthesized in a bottom-up approach. Concentration-dependent uptake and cytotoxicity of PET NPs in macrophages are shown. The fabrication of well-characterized NPs, derived from high-commodity polymers, will support future studies to assess effects on biological systems.
