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Enantioselective synthesis and pharmacology of 11-hydroxy-(1 ' S,2 ' R)-dimethylheptyl-Delta(8)-THC

Liddle, J., Huffman, JW., Wiley, J., & Martin, BR. (1998). Enantioselective synthesis and pharmacology of 11-hydroxy-(1 ' S,2 ' R)-dimethylheptyl-Delta(8)-THC. Bioorganic and Medicinal Chemistry Letters, 8(16), 2223-2226.

Abstract

An enantioselective synthesis of the (1'S,2'R)-dimethylheptyl cannabinoid side chain has been developed and employed in the synthesis of 11-hydroxy-(1'S,2'R)-dimethylheptyl-Delta(8)-THC (3). Pharmacology, in vivo and in vitro, indicate (3) to be one of the most potent traditional cannabinoids known. (C) 1998 Elsevier Science Ltd. All rights reserved

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