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Enhancing colloidal stability and cellular uptake of polymeric nanoparticles through DNA surface-functionalization
Banga, R. J., Krovi, S. A., Narayan, S. P., Sprangers, A. J., Liu, G., Mirkin, C. A., & Nguyen, S. T. (2017). Drug-loaded polymeric spherical nucleic acids: Enhancing colloidal stability and cellular uptake of polymeric nanoparticles through DNA surface-functionalization. Biomacromolecules, 18(2), 483-489. https://doi.org/10.1021/acs.biomac.6b01563
Small-sized (∼65 nm) doxorubicin (Dox)-loaded polymeric nanoparticles (PNPs) were modified with oligonucleotides to form colloidally stable Dox-loaded polymeric spherical nucleic acid (Dox-PSNA) nanostructures in biological media. The nucleic acid shell facilitates the cellular uptake of Dox-PSNA, which results in in vitro cytotoxicity against SKOV3 cancer cells.
