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Handels, R. L. H., Green, C., Gustavsson, A., Herring, W. L., Winblad, B., Wimo, A., Sköldunger, A., Karlsson, A., Anderson, R., Belger, M., Brück, C., Espinosa, R., Hlávka, J. P., Jutkowitz, E., Lin, P.-J., Mendez, M. L., Mar, J., Shewmaker, P., Spackman, E., ... IPECAD modeling workshop 2020 participants (2023). Cost-effectiveness models for Alzheimer's disease and related dementias: IPECAD modeling workshop cross-comparison challenge. Alzheimer's and Dementia, 19(5), 1800-1820. https://doi.org/10.1002/alz.12811
INTRODUCTION: The credibility of model-based economic evaluations of Alzheimer's disease (AD) interventions is central to appropriate decision-making in a policy context. We report on the International PharmacoEconomic Collaboration on Alzheimer's Disease (IPECAD) Modeling Workshop Challenge.
METHODS: Two common benchmark scenarios, for the hypothetical treatment of AD mild cognitive impairment (MCI) and mild dementia, were developed jointly by 29 participants. Model outcomes were summarized, and cross-comparisons were discussed during a structured workshop.
RESULTS: A broad concordance was established among participants. Mean 10-year restricted survival and time in MCI in the control group ranged across 10 MCI models from 6.7 to 9.5 years and 3.4 to 5.6 years, respectively; and across 4 mild dementia models from 5.4 to 7.9 years (survival) and 1.5 to 4.2 years (mild dementia).
DISCUSSION: The model comparison increased our understanding of methods, data used, and disease progression. We established a collaboration framework to assess cost-effectiveness outcomes, an important step toward transparent and credible AD models.
