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A group of retinoids having "vitamin A type" activity which have
the structure ##STR1## wherein R3 is a
trimethylcyclohexenylethylene, tetramethyltetrahydronaphthalene or
methoxytrimethylphenylethylene group; R1 and R2 which are different
are selected from --OH, --OR4 and --NHR, provided one of R1 and R2
is OH; R4 is alkyl of 1 to 20 carbons; and R is selected from the
group consisting of hydrogen, alkyl of 1 to 4 carbons, hydroxyalkyl
of 1 to 4 carbons, alkylhydroxyalkyl of 1 to 4 carbons, phenyl,
hydroxyphenyl and carboxyphenyl, and R5 is a lactone or lactam of
the structure ##STR2## and X is oxygen or NR where R is as above,
and the pharmaceutically acceptable salts thereof.