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Krovi, S. A., Smith, D., & Nguyen, S. T. (2010). "Clickable" polymer nanoparticles: A modular scaffold for surface functionalization. Chemical Communications, 46(29), 5277-9. https://doi.org/10.1039/c0cc00232a
The versatility of copper-catalyzed alkyne-azide coupling (CuAAC) in functionalizing drug-loaded polymer nanoparticles is demonstrated via the modification of surfaces of acetylene-functionalized PNPs with folate, biotin, and gold nanoparticles.