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Characterization of the form of cytochrome P450 induced by methylenedioxy compounds in rats and mice
Bridges , J. W., & Fennell, T. R. (1980). Characterization of the form of cytochrome P450 induced by methylenedioxy compounds in rats and mice. In M. J. Coon, A. H. Conney, R. W. Estabrook, H. V. Gelboin, J. R. Gillette, & P. J. O'Brien (Eds.), Microsomes, drug oxidations and chemical carcinogenesis (pp. 993-996). Elsevier Academic Press.
A number of methylenedioxyphenyl compounds induce in rats and mice a form of P-450 which is different from that induced by phenobarbitone, 20 methylcholanthrene or pregnenolone carbonitrile. A close correlation between the size of the reduced spectrum which has a maximum at 455nm (and is displaceable by 2-heptylbenzimidazole) and the extent of induction is observed in both rats and mice.
