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Camptothecin analogs as potent inhibitors of topoisomerase I

Wall, M., Wani, M., Nicholas, A., & Manikumar, G. (1993). Camptothecin analogs as potent inhibitors of topoisomerase I. (U.S. Patent No. 5244903). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=5244903

Abstract

A method for synthesizing camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase.

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