RTI uses cookies to offer you the best experience online. By clicking “accept” on this website, you opt in and you agree to the use of cookies. If you would like to know more about how RTI uses cookies and how to manage them please view our Privacy Policy here. You can “opt out” or change your mind by visiting: http://optout.aboutads.info/. Click “accept” to agree.
An association study of DRD5 with smoking initiation and progression to nicotine dependence
Sullivan, P. F., Neale, M. C., Silverman, M. A., Harris-Kerr, C., Myakishev, M. V., Wormley, B., Webb, B. T., Ma, Y., Kendler, K. S., & Straub, R. E. (2001). An association study of DRD5 with smoking initiation and progression to nicotine dependence. American Journal of Medical Genetics, 105(3), 259-265. https://doi.org/10.1002/ajmg.1301
A large body of genetic epidemiological data strongly implicate genetic factors in the etiology of smoking behavior. Polymorphisms of genes in the dopaminergic system are plausible functional candidate genes and a linkage and an association study suggested that the type 5 dopamine receptor gene (DRD5) may be etiologically involved. We investigated the association of four DRD5 polymorphisms with smoking initiation and progression to nicotine dependence in a population-based sample of over 900 subjects. For smoking initiation, there was no significant association with the four DRD5 markers we studied; however, maximum likelihood analyses suggested the presence of a haplotype protective against smoking initiation. For progression to nicotine dependence, there were no strongly significant associations with the four DRD5 markers or for the estimated haplotypes. These data are not consistent with a strong etiological role for DRD5 in the etiology of these complex smoking behaviors.
