Association between smoking and uveitis: Results from the Pacific Ocular Inflammation Study

Rachel Weinrib; Erica Nicole Browne; Brenton Yuen; Vivien M. Tham; Erica Nicole Browne; Rachel Weinrib; Durga S. Borkar; John V. Parker; Aileen Uchida; Aleli C. Vinoya; Nisha R. Acharya

Association between smoking and uveitis

Results from the Pacific Ocular Inflammation Study

Yuen, B., Tham, V. M., Browne, E. N., Weinrib, R., Borkar, D. S., Parker, J. V., Uchida, A., Vinoya, A. C., & Acharya, N. R. (2015). Association between smoking and uveitis: Results from the Pacific Ocular Inflammation Study. Ophthalmology. https://doi.org/10.1016/j.ophtha.2015.02.034

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Abstract

Purpose
To assess whether cigarette smoking is associated with the development of uveitis in a population-based setting.

Design
Retrospective, population-based, case-control study.

Participants
Patients aged ≥18 years who were seen at a Kaiser Permanente Hawaii clinic between January 1, 2006, and December 31, 2007. Analysis included 100 confirmed incident uveitis cases, 522 randomly selected controls from the general Kaiser Hawaii population, and 528 randomly selected controls from the Kaiser Hawaii ophthalmology clinic.

Methods
International Classification of Diseases, 9th revision (ICD-9), diagnosis codes were used to identify possible uveitis cases. A uveitis fellowship–trained ophthalmologist then conducted individual chart review to confirm case status. Multivariate logistic regression models were used to evaluate the association between smoking and uveitis, adjusting for age, sex, race, and socioeconomic status.