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7-substituted camptothecin and camptothecin analogs and methods for producing the same
Wani, M., Manikumar, G., Wall, M., & [legal representative] Wall, MA. (2006). 7-substituted camptothecin and camptothecin analogs and methods for producing the same. (U.S. Patent No. 7067666). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=7067666
Methods of forming camptothecin compounds which are effective
anti-tumor compounds are disclosed. These compounds inhibit the
enzyme topoisomerase I and may alkylate DNA of the associated
topoisomerase I-DNA cleavable complex.