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17.beta.-nitro-11.beta.-arylsteroids and their derivatives having agonist or antagonist hormonal properties

Cook, C., Kepler, J., Shetty, RS., Bartley, GS., & Lee, DY. (1999). 17.beta.-nitro-11.beta.-arylsteroids and their derivatives having agonist or antagonist hormonal properties. (U.S. Patent No. 5962444). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=5962444

Abstract

The invention is directed to 17.beta.-nitro-11.beta.-arylsteroids of formula I: ##STR1## wherein R.sup.1, R.sup.6, R.sup.7, R.sup.12 and X are as defined by the specification. The compounds exhibit potent antiprogestational activity and are useful in the treatment of fibroids, endometriosis, cervical ripening prior to delivery, hormone replacement therapy and in the control of fertility.

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