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A camptothecin analog having the structure shown below: ##STR1##
wherein R is NO.sub.2, NH.sub.2, NHCOCHR.sup.1 NR.sup.2 R.sup.3,
where R.sup.1 is the side-chain of an .alpha.-amino acid and
R.sup.2 and R.sup.3, independently are hydrogen or a lower alkyl
group or R.sup.3 is a peptide unit containing 1-3 amino acid units
bonded to the nitrogen through a peptide bond, NHCO--C.sub.2-8
-alkylene-X or NHCO--C.sub.2-8 -alkenylene-X, where X is COOH or
CONR.sup.2 --(CH.sub.2).sub.n --NR.sup.2 R.sup.3, n=1-10 and
R.sup.2 and R.sup.3 are as defined above, NHCO--Z--(CH.sub.2).sub.n
--NR.sup.2 R.sup.3, where z=oxygen or NH, or ##STR2## where m+y=3-6
and salts thereof.