RTI uses cookies to offer you the best experience online. By clicking “accept” on this website, you opt in and you agree to the use of cookies. If you would like to know more about how RTI uses cookies and how to manage them please view our Privacy Policy here. You can “opt out” or change your mind by visiting: http://optout.aboutads.info/. Click “accept” to agree.
10, 11-difluoromethylenedioxycamptothecin compounds with topoisomerase I inhibition
Wall, M., Wani, M., Manikumar, G., Balasubramanian, N., & Vyas, D. (2001). 10, 11-difluoromethylenedioxycamptothecin compounds with topoisomerase I inhibition. (U.S. Patent No. 6268375). http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=6268375
Camptothecin compounds having a C.sub.10 11 O--(CF.sub.2).sub.n O group where n is 1 or 2 are effective anti-tumor compounds. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I-DNA cleavable complex.