RTI uses cookies to offer you the best experience online. By clicking “accept” on this website, you opt in and you agree to the use of cookies. If you would like to know more about how RTI uses cookies and how to manage them please view our Privacy Policy here. You can “opt out” or change your mind by visiting: http://optout.aboutads.info/. Click “accept” to agree.
Octaphlorethol A isolated from <i>Ishige foliacea</i> prevents and protects against high glucose-induced oxidative damage <i>in vitro</i> and <i>in vivo</i>
Kang, M.-C., Kim, K.-N., Lakmal, H. H. C., Kim, E.-A., Wijesinghe, W. A. J. P., Yang, X., Heo, S.-J., & Jeon, Y.-J. (2014). Octaphlorethol A isolated from <i>Ishige foliacea</i> prevents and protects against high glucose-induced oxidative damage <i>in vitro</i> and <i>in vivo</i>Environmental Toxicology and Pharmacology, 38(2), 607-615. https://doi.org/10.1016/j.etap.2014.08.001
We investigated the protective effect of octaphlorethol A (OPA) isolated from Ishige foliacea against high-glucose-induced oxidative damage, as indicated by reactive oxygen species (ROS) generation, lipid peroxidation, and cell death, in human umbilical vein endothelial cells (HUVECs) and in a zebrafish model. OPA treatment significantly and dose-dependently decreased ROS generation, lipid peroxidation, and cell death in HUVECs and in a zebrafish model. Our results show that OPA can protect HUVECs and zebrafish against high glucose by suppressing intracellular ROS generation, lipid peroxidation, and cell death. (C) 2014 Elsevier B.V. All rights reserved.