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Interaction of serotonin transporter linked polymorphic region and childhood neglect on criminal behavior and substance use for males and females
Vaske, J., Newsome, J., & Wright, J. P. (2012). Interaction of serotonin transporter linked polymorphic region and childhood neglect on criminal behavior and substance use for males and females. Development and Psychopathology, 24(1), 181-193. https://doi.org/10.1017/S0954579411000769
Childhood neglect has been cited as a risk factor for later substance abuse and criminal behavior. However, a large body of literature shows that a substantial percentage of neglected and abused individuals do not go on to abuse substances or engage in criminal behavior. The current study investigates whether a genetic variant (serotonin transporter linked polymorphic region [5-HTTLPR]) in the 5-hydroxytryptamine (5-HTT) gene moderates the effect of childhood neglect on alcohol use problems, marijuana use, and criminal behavior. Data from the National Longitudinal Study of Adolescent Health shows that 5-HTTLPR conditions the effect of neglect on marijuana use for females, but not for males. Findings also reveal a significant gene environment correlation between 5-HTTLPR and neglect for females only. These results suggest that 5-HTTLPR is associated with an increased risk of neglect for females, and it also increases neglected females' risk of abusing marijuana.
