Chunyang Jin

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Targeting the relaxin-3/RXFP3 system: A patent review for the last two decades

Design, synthesis, and structure–activity relationship studies of novel GPR88 agonists (4-substituted-phenyl)acetamides based on the reversed amide scaffold

Novel RXFP3 negative allosteric modulator RLX-33 reduces alcohol self-administration in rats

Improvement of the metabolic stability of GPR88 agonist RTI-13951-33: Design, synthesis, and biological evaluation

Synthesis and pharmacological validation of a novel radioligand for the orphan GPR88 receptor

The GPR88 agonist RTI-13951-33 reduces alcohol drinking and seeking in mice

Role of GPR88 in ethanol drinking: A new pharmacological target

Discovery and characterization of the first nonpeptide antagonists for the relaxin-3/RXFP3 system

Rxfp3 small molecule antagonist decreases alcohol self-administration in rats

Indole-containing amidinohydrazones as nonpeptide, dual RXFP3/4 agonists: Synthesis, structure–activity relationship, and molecular modeling studies

Evaluation of amide bioisosteres leading to 1,2,3-triazole containing compounds as GPR88 agonists: Design, synthesis, and structure-activity relationship studies

Pyrazole agonist of the apelin receptor improves symptoms of metabolic syndrome in mice

Stereospecific inhibition of ethanol potentiation on glycine receptor by M554 stereoisomers

Design, synthesis, and structure-activity relationship studies of (4-alkoxyphenyl)glycinamides and bioisosteric 1,3,4-oxadiazoles as GPR88 agonists

Discovery of a potent, selective, and brain-penetrant small molecule that activates the orphan receptor GPR88 and reduces alcohol intake

Development and validation of a high-throughput calcium mobilization assay for the orphan receptor GPR88

Topoisomerase I (Top1): a major target of FL118 for its antitumor efficacy or mainly involved in its side effects of hematopoietic toxicity?

Design, synthesis and pharmacological evaluation of 4-hydroxyphenylglycine and 4-hydroxyphenylglycinol derivatives as GPR88 agonists

1-substituted 4-arylpiperazine as kappa opioid receptor antagonists

Effect of substitution on the aniline moiety of the GPR88 agonist 2-PCCA: Synthesis, structure-activity relationships, and molecular modeling studies