James M. Mathews
Director, Drug Metabolism and Pharmacokinetics
James Mathews, PhD, has more than 25 years of experience directing investigations of the metabolism and disposition of drugs, commodity chemicals, and crop protection products for industry and government. In 1985, Dr. Mathews joined RTI to direct ADME investigations of xenobiotics in mammals. He developed a full-service DMPK department that conducts studies at the molecular and biochemical through cellular and subcellular levels, and with isolated organs and in vivo models. He is the principal investigator (PI) on the NTP project “Chemical Disposition in Mammals” examining the toxic action of chemicals. Dr. Mathews is also the PI on work for the National Institute of Neurological Disorders and Stroke to screen drugs for treatment of spinal muscular atrophy, and he writes expert dossiers on drugs proposed for the treatment of Parkinson Disease. He has authored more than 40 peer-reviewed journal articles, is a diplomate of the American Board of Toxicology, and serves on the executive committee of the Research Triangle Park Drug Metabolism Discussion Group. Dr. Mathews has an adjunct faculty appointment with the School of Pharmacy at the University of North Carolina, Chapel Hill.
Education
PhD, Pharmaceutical Chemistry, University of California, San Francisco; BS, Chemistry, California State University, Northridge.
Publications
Mathews, J.M., Brown, S.S., Patel, P.R., Black, S.R., Banks, T.T., Etheridge, A.S., Fennell, T.R., Snyder, R.W., et al. (Feb 2013)
Mathews, J.M., Zhan, Q., Etheridge, A.S., Patel, P.R., Black, S.R., Banks, T.T., Fennell, T.R., Snyder, R.W., Burgess, J.P., et al. (Dec 2012)
Fulp, A., Bortoff, K., Zhang, Y., Seltzman, H., Mathews, J., Snyder, R., Fennell, T., & Maitra, R. (Nov 2012)
Fulp, A., Bortoff, K., Seltzman, H., Zhang, Y., Mathews, J., Snyder, R., Fennell, T., & Maitra, R. (Mar 2012)
Mathews, J.M., Watson, S.L., Snyder, R.W., Burgess, J.P., & Morgan, D.L. (Dec 2010)
Expertise
- Drug Metabolism
- Pharmacokinetics